September 2021 is fundamentally different from 2020 in another crucial metric: It now is a pandemic of the unvaccinated. As a pediatrician working at the major children’s hospital in our area, I saw it during my week on service which ended just a few hours ago: The teenagers and young adults admitted with COVID—some intubated, some dying from the disease—come from all walks of life. Widely diverse and yet they all share one characteristic: They are unvaccinated.